Urine metals concentrations and dyslexia among children in China

Urine metals concentrations and dyslexia among children in China

Blog Article

Background: Exposures to heavy metals has been linked to many developmental disorders.However, few studies have investigated the effects of exposure and co-exposure to metals on dyslexia, especially with regard to dyslexics in China.Objectives: To investigate the association between urine metal concentrations and dyslexia in a case-control study among children Drinks in China.Methods: A case-control study was conducted in the Tongji Reading Environment and Dyslexia (READ) research program.

A total of 228 dyslexics and 228 controls were matched on gender, age (within one year), and grade.The concentrations of 21 urine metals were measured by an inductively coupled plasma-mass spectrometer (ICP-MS).Multivariable conditional logistic regression models were applied to estimate the adjusted odds ratios (ORs) of Chinese dyslexia.Results: After adjusting for potential confounders, two metals (selenium and argentum) were significantly associated with dyslexia in single-metal multivariable models.

Argentum was positively associated with the risk of dyslexia, while selenium was toys negatively associated.In the multiple-metal model, compared with extreme quartiles, the ORs (95% CIs) for selenium was 0.36 (95% CI: 0.14–0.

93; Ptrend = 0.029).In the joint association analysis, children with higher levels of urine argentum and lower level of urine selenium had a significantly higher risk of dyslexia than those with low levels of argentum and selenium (OR = 5.06, 95% CI: 1.

67–18.84).Conclusions: The findings suggest that exposure to selenium and argentum may relate to dyslexia in China.Longitudinal studies are needed to further evaluate these relationships and investigate potential mechanisms.